Wirkungen
Senk Darm-pH durch Produktion von Milchsäure
L. acidophilus exhibited strong anti-inflammatory activities
L. acidophilus reduziert die Aktivität von Enzymen wie Azo-Reduktase, Nitro-Reduktase, und β-Glucosidase, die cancerogene Precursors in aktive Cancerogene umwandeln.
reduce serum cholesterol level [29,
30]. L. acidophilus can absorb and assimilate cholesterol
L. acidophilus can improve lactose digestion or symptoms in lactoseintolerant
patients [54, 55]. Among these studies, in vitro evaluation of the lactase levels of various probiotics has
shown that the lactase levels of L. acidophilus NCFM were high when compared to all of the probiotics tested.
- Inhibit oxidative stress by modulating the productions of MDA, oxLDL and SOD
- suppress inflammatory status by regulating TNF-α and IL-10 levels;
- inhibit NPC1L1 expression in the small intestine;
- inhibit the developmentof atherosclerosis
- Assimilate cholesterol and control cholesterol levels. [40, 41]
- L. acidophilus NS1 Reduce plasma LDL-C by increasing hepatic LDLR and SREBP2-expression.
- Improve gastrointestinal diseases
- alleviate Tcell-induced colitis by significantly reducing the proinflammatory response;
- preserve microbiome composition and intestinal barrier function;
- reverse histopathological damage caused by colitis;
- reduce the level of toxic metabolites.
- L. acidophilus PTCC 1643 Modulate the expression of TLR2 and TLR4 in HT29 intestinal epithelial cells challenged with SesE;
- enhance antiinflammatory effects
- L. acidophilus NCFM Improve lactose intolerance
- L. acidophilus DDS-1 Assist in breaking down lactose; improve lactose intolerance symptoms such as diarrhea, cramps and vomiting.
- L. acidophilus ATCC 4356 Prevent and treat colon cancer, liver cancer and other cancers
- The exopolysaccharides of the strain have immunomodulatory and antitumor activities;
- regulate the TLR2/STAT-3/P38-MAPK-pathway associated with inflammation against HCC.
- L. acidophilus NCFM Stimulate the immune response;
- reduce the activities of β-glucuronase, nitroreductase, azoreductase and other microbial enzymes;
- produce compounds that inhibit tumor proliferation;
- reduce the incidence of colon cancer and inhibit the growth of colon tumors.
- L. acidophilus NCFM regulate immune capacity
- Reduce levels of pro-inflammatory cytokines significantly and mobilize a systemic immune response;
- limit pathogen colonization in the body
- control metabolic disorders.
- L. acidophilus ATCC314 manage inflammatory disorders
- Regulate the secretion of inflammatory cytokines;
- reduce oxidative stress.
mögliche Indikationen
Some probiotic studies have shown that L. acidophilus can improve lactose digestion or symptoms in lactoseintolerant
patients [54, 55]. Among these studies, in vitro evaluation of the lactase levels of various probiotics has
shown that the lactase levels of L. acidophilus NCFM were high when compared to all of the probiotics tested.
Multiple studies have also shown that NCFM can improve lactose digestion and relieve symptoms of lactose
intolerance such as bloating and diarrhea [56, 57]. A study speculated that the bacteria might metabolize lactose
during digestion and transport it through the gastrointestinal tract. The study by Pakdaman et al. found that
L. acidophilus DDS-1, a unique and edible strain, can improve lactose intolerance symptoms such as diarrhea,
cramps, and vomiting [58]. However, a number of studies have shown the opposite effects. For example,
Newcomer et al. demonstrated that dairy products containing L. acidophilus NCFM did not significantly improve
human lactose intolerance [59-61]. The reason for these contradictory results has been associated with the levels
of NCFM of L. acidophilus. Therefore, in order to better apply the functional properties of L. acidophilus and to
improve lactose intolerance, it is essential to explore and adjust the probiotics levels and the formula with each
product.
Prevention and Treatment
Prevention and Treatment of Cancer
Probiotics are considered a safe and cost-effective way to prevent or treat a variety of cancers, including colon and liver cancer.
Several studies have suggested that consumption of cultured dairy products may reduce colon cancer risk, since the effects of diet are mediated by metabolic effects of intestinal organisms. The activities of β-glucuronase, nitroreductase, azoreductase and other microbial enzymes have been used to monitor colon cancer changes.
Goldin and Gorbach observed that adding live L. acidophilus into the diet of carnivorous rats significantly reduced azoreductase, nitroreductase and glucuronidase activity [24, 25]. The incidence of colon
cancer in rats with L. acidophilus NCFM was also lower. Their later study found that NCFM alongside antibiotics
inhibited the growth of colon tumors in rats. In human, daily consumption of milk containing NCFM reduced the
activity of these three fecal enzymes by a factor of two- to four-fold and reduced the incidence of colon cancer [24,
25]. In addition, they found that nitroreductase activity continued to decrease even three weeks after fermented
milk intake was stopped, thus indicating a long-term change in colonic flora [24, 25].
Studies have shown that the extracellular polysaccharides (EPSs) synthesized by L. acidophilus have exerted
health benefits by stimulating the immune response and fighting tumor cells [62]. The anticancer and
immunomodulatory activities of EPSs synthesized by L. acidophilus have been proven to combat colon cancer and
inflammatory liver cancer. Khedr and colleagues used male rats as a model and confirmed that L. acidophilus
ATCC 4356 EPSs had immunomodulatory effects on liver cancer induced by diethylnitrosamine (DEN) and gamma radiation (IR) [63]. They proposed that L. acidophilus ATCC 4356 EPSs might be used as a safe and
effective probiotic to prevent and treat liver cancer.
L. acidophilus has been shown to have potential applications in the prevention and control of genitourinary and vaginal infections.
Reid et al. precultured L. acidophilus NCFM with urinary and vaginal epithelial cells from healthy women and subsequently exposed them to different urinary tract pathogens. Results showed that NCFM competitively excluded pathogens and effectively prevented and suppressed urinary tract and vaginal infections [69].
Rheumatoid arthritis (RA) is a common inflammatory joint disease. It has been reported that the ingestion of
L. acidophilus ATCC 314 exerted anti-inflammatory and potent antioxidant properties in a collagen-induced
arthritis (CIA) rat model [70, 71]. This suggests that L. acidophilus is a promising treatment that should be tested
further in RA patient preclinical trials.